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While higher levels of testosterone in women with polycystic ovarian syndrome are not protective against lipedema, the adipose tissue in women with this condition may be predisposed to lipedema due to abdominal obesity and inflammation associated with pre-diabetes or diabetes

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Indeed, the ability of serine to be synthesized from the glycolytic intermediate, 3-phosphoglycerate, directly ties glucose metabolism to the active THF pool

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids